Structure of PDB 7r50 Chain J

Receptor sequence
>7r50J (length=440) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
VRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVVA
NMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTPV
TLSPEDSVSDANALLHKRAHGAAVVVFEGRPIFVTAPVGTDPREVFDLLE
HAPIDVAVMTAPDGTLAGVLTRTGAIRAGIYTPAVDAKGRLRIAAAVGIN
GDVGAKAQALAEAGADLLVIDTAHGHQAKMLDAIKAVASLDLGLPLVAGN
VVSAEGTRDLIEAGASIVKVGVGPGAMCTTRMMTGVGRPQFSAVVECAAA
ARQLGGHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLLFD
RDDRPYKESYGMASKRAVAASSFDRARKGLFEEGISTSRMSLDPARGGVE
DLLDHITSGVRSTCTYVGAANLPELHEKVVLGVQSAAGFA
3D structure
PDB7r50 The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain.
ChainJ
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.7.1.7: GMP reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP J M53 G300 A301 C303 D336 G337 G338 G359 S360 G386 M387 A388 R391 M52 G275 A276 C278 D311 G312 G313 G334 S335 G361 M362 A363 R366
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003920 GMP reductase activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006166 purine ribonucleoside salvage
GO:0032264 IMP salvage
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:7r50, PDBe:7r50, PDBj:7r50
PDBsum7r50
PubMed35338694
UniProtA0QYE8|GUAB1_MYCS2 GMP reductase (Gene Name=guaB1)

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