Structure of PDB 7mdz Chain J

Receptor sequence

>7mdzJ (length=170) Species: 9986 (Oryctolagus cuniculus)

KENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTV
RSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGF
GIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRI
SKEEAMRWFQQKYDGIILPG

3D structure

• PDB: 7mdz Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation.
• Chain: J
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	J	K19 C21 N23 S51 A53 R54 F60 I62 I68 N97 N98 S100 T102 N104 G106 F107 Q110 G127 D129 Y131 K145	K12 C14 N16 S44 A46 R47 F53 I55 I61 N90 N91 S93 T95 N97 G99 F100 Q103 G120 D122 Y124 K138
BS02	rna	J	N10 M12 R13 Q46 T47 V49 T73 R75 G138 S140 I141 K144 K145 R146 R147 C150 I151 G152 A153 K154 H155	N3 M5 R6 Q39 T40 V42 T66 R68 G131 S133 I134 K137 K138 R139 R140 C143 I144 G145 A146 K147 H148
BS03	rna	J	Y55 T56 R64	Y48 T49 R57

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7mdz, PDBe:7mdz, PDBj:7mdz
• PDBsum: 7mdz
• PubMed: 34403584
• UniProt: G1TUB8|RL11_RABIT Large ribosomal subunit protein uL5 (Gene Name=RPL11)