Structure of PDB 6xsw Chain J

Receptor sequence
>6xswJ (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
AACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNN
SRCDPACSSPACLYDNFDCERTCNPVYEKYCADHFADGRCDQGCNTEECG
WDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLR
FRLDAHGQAMVFPYGSVVMLEIDNRLCLQSPDHCFPDAQSAADYLGALSA
VERLDFPYPLRDVRGEPL
3D structure
PDB6xsw NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
ChainJ
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA J K1396 D1399 R1401 D1403 D1414 D1417 K6 D9 R11 D13 D24 D27
BS02 CA J H1479 D1482 R1484 D1486 D1497 D1500 H84 D87 R89 D91 D102 D105
BS03 CA J L1437 N1440 R1442 D1444 D1455 D1458 L47 N50 R52 D54 D65 D68
Gene Ontology
Biological Process
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6xsw, PDBe:6xsw, PDBj:6xsw
PDBsum6xsw
PubMed34095881
UniProtQ9UM47|NOTC3_HUMAN Neurogenic locus notch homolog protein 3 (Gene Name=NOTCH3)

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