Structure of PDB 6tlj Chain J

Receptor sequence

>6tljJ (length=504) Species: 9606 (Homo sapiens) [Search protein sequence]

NLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTA
QYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMSQSSIK
SSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQ
EEKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQE
NLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELN
KANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTL
EKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYG
LTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDAL
EKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNA
STYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGD
SEAY

3D structure

PDB

6tlj A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.

Chain

Resolution

3.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	J	H174 Y212 Y243 C245 E277 H342 Y373 E377 F403 H406 V410 F413 K443 E445 P446 N449 N450 H453 R456 K457 K459 N478 S480 A484 Y487 S490 L491 F514 M518 M525	H145 Y183 Y214 C216 E248 H313 Y344 E348 F374 H377 V381 F384 K414 E416 P417 N420 N421 H424 R427 K428 K430 N449 S451 A455 Y458 S461 L462 F485 M489 M496

Gene Ontology

	Molecular Function
GO:0005515	protein binding

	Biological Process
GO:0007346	regulation of mitotic cell cycle
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent catabolic process
GO:0045842	positive regulation of mitotic metaphase/anaphase transition
GO:0051301	cell division
GO:0051445	regulation of meiotic cell cycle
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0141198	protein branched polyubiquitination

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005680	anaphase-promoting complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0072686	mitotic spindle

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6tlj, PDBe:6tlj, PDBj:6tlj
PDBsum	6tlj
PubMed	32307883
UniProt	Q13042\|CDC16_HUMAN Cell division cycle protein 16 homolog (Gene Name=CDC16)

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