Structure of PDB 6om8 Chain J

Receptor sequence

>6om8J (length=456) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]

MTDQVFGKVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEW
NSDKLPIYEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTDL
KYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNLKFQV
LSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENWVPRN
RIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVAHAVG
YDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQGVINI
NNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIHVIKH
LMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAAARGA
HAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIGFRTF
AIGTSP

3D structure

PDB

6om8 Conservation of Atypical Allostery inC. elegansUDP-Glucose Dehydrogenase.

Chain

Resolution

2.449 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	T136 E172 K227 N231 C283 D287
Catalytic site (residue number reindexed from 1)	T125 E159 K214 N218 C270 D274
Enzyme Commision number	1.1.1.22: UDP-glucose 6-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UDX	J	G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 R353	G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y102 S124 T125 R340
BS02	UDX	J	T136 F169 L170 A171 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447	T125 F156 L157 A158 K214 I225 F259 Q261 S263 F266 G267 C270 F271 F332 K333 R434

Gene Ontology

	Molecular Function
GO:0003979	UDP-glucose 6-dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding
GO:0051287	NAD binding

	Biological Process
GO:0002009	morphogenesis of an epithelium
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006065	UDP-glucuronate biosynthetic process
GO:0009792	embryo development ending in birth or egg hatching
GO:0018991	egg-laying behavior
GO:0022414	reproductive process
GO:0040025	vulval development

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6om8, PDBe:6om8, PDBj:6om8
PDBsum	6om8
PubMed	31616809
UniProt	Q19905\|UGDH_CAEEL UDP-glucose 6-dehydrogenase (Gene Name=sqv-4)

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