Structure of PDB 6nud Chain J

Receptor sequence
>6nudJ (length=741) Species: 1308 (Streptococcus thermophilus) [Search protein sequence]
KEKIDLFYGALLHDIGKVIQRATGERKKHALVGADWFDEIADNQVISDQI
RYHMANYQSDKLGNDHLAYITYIADNIASGSAKIWDTYTNQADIFNVFGA
QTDKRYFKPTVLNLKSKPNFASATYEPFSKGDYAAIATRIKNELAEFEFN
QAQIDSLLNLFEAILSFVPSSTNSKEIADISLAEHSRLTAAFALAIYDYL
EDKGRHNYKEDLFTKASAFYEEEAFLLASFDLSGIQDFIYNIATSGAAKQ
LKARSLYLDFMSEYIADSLLDKLGLNRANLLYVGGGHAYFVLANTEKTVE
TLVQFEKDFNQFLLANFQTRLYVAFGWGSFAAKDIMSELNSPESYRQIYQ
KASRMISEKKISRYDYRTLMLLNRGGKSSERECEICHSVENLVSYHDQKV
CDICRGLYQFSKEIAHDHFIITENEGLPIGPNACLKGVAFEKLSQESFSR
VYVKNDYKAGTIKATHVFVGDYQCDEIHKYAALSKNEDGLGIKRLAVVRL
DVDDLGAAFMAGFSRQGNGQYSTLSRSATFSRSMSLFFKVYINQFASDKK
LSIIYAGGDDVFAIGSWQDIIAFTVELRQNFIKWTNGKLTLSAGIGLFAD
KTPISLMAHQTGELEEAAKGNEKDSISLFSSDYTFKFDRFITNVYDDKLE
QIRYFFNHQDERGKNFIYKLIELLRNYESEEKMNVARLAYYLTRLEELTD
KDERDKFKQFKKLFFKWYTNNESDRKEAELALLLYVYEIRK
3D structure
PDB6nud Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry.
ChainJ
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna J K617 E677 R678 K680 N681 L714 R756 K757 K601 E661 R662 K664 N665 L698 R740 K741
BS02 ATP J Y298 H303 L521 Y282 H287 L505
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0016740 transferase activity
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6nud, PDBe:6nud, PDBj:6nud
PDBsum6nud
PubMed30814678
UniProtA0A0A7HFE1|CAS10_STRTR CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=cas10)

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