Structure of PDB 6hk6 Chain J

Receptor sequence
>6hk6J (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
GKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNK
VLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQM
GVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLHNVSWLYLSRLSAMKE
FAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDE
AMELIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWY
FDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVS
3D structure
PDB6hk6 Crystal structure of human RIOK2 bound to a specific inhibitor.
ChainJ
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G8H J M101 I111 A121 I191 G193 I235 I245 M100 I110 A120 I180 G182 I224 I234
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6hk6, PDBe:6hk6, PDBj:6hk6
PDBsum6hk6
PubMed30991936
UniProtQ9BVS4|RIOK2_HUMAN Serine/threonine-protein kinase RIO2 (Gene Name=RIOK2)

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