Structure of PDB 6hc3 Chain J

Receptor sequence

>6hc3J (length=191) Species: 9606 (Homo sapiens) [Search protein sequence]

SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPD
SKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAM
TKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLS
DSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRT

3D structure

PDB

6hc3 DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region.

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	J	K51 K52 V54 L58 K62 R140 K146 K147 R157 Y162 Q179 L182 K186 Y211 R232 R233 T234	K8 K9 V11 L15 K19 R97 K103 K104 R114 Y119 Q136 L139 K143 Y168 R189 R190 T191	PDBbind-CN: Kd=13.6nM
BS02	dna	J	S55 Y57 L58 T78 I81 R82 A85 W88 R89 Q100 Y103 W107 K139 M143 K146 K147 K156 R157 N163 V166 F170 P178	S12 Y14 L15 T35 I38 R39 A42 W45 R46 Q57 Y60 W64 K96 M100 K103 K104 K113 R114 N120 V123 F127 P135	PDBbind-CN: Kd=13.6nM

External links

PDB	RCSB:6hc3, PDBe:6hc3, PDBj:6hc3
PDBsum	6hc3
PubMed	31114891
UniProt	Q00059\|TFAM_HUMAN Transcription factor A, mitochondrial (Gene Name=TFAM)

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