Structure of PDB 6h25 Chain J

Receptor sequence
>6h25J (length=868) Species: 9606 (Homo sapiens) [Search protein sequence]
MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEP
QPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRN
RSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNNRAIR
VAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKS
LTANPELIDRFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHK
EIILQGLKHLNRAVHEDIVAVELLPKSQWPTGRVVGIIKRNWRPYCGMLS
KSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRY
PNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITE
KDMKNREDLRHLCICSVDPPGCTDINDALHCRELENGNLEVGVHIADVSH
FIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFS
CIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLR
GLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNS
MVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNL
EIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDND
FHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLA
DICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIV
VLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKI
MLDSSNLQHQKIRMSLVE
3D structure
PDB6h25 Distinct and evolutionary conserved structural features of the human nuclear exosome complex.
ChainJ
Resolution3.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D479 D485 N487 D488 Y590 R780
Catalytic site (residue number reindexed from 1) D418 D424 N426 D427 Y529 R719
Enzyme Commision number 3.1.13.-
3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna J P480 N487 Y531 R536 L632 S633 R689 H691 Q750 A751 H764 Y772 H774 T776 Q825 P419 N426 Y470 R475 L571 S572 R628 H630 Q689 A690 H703 Y711 H713 T715 Q764
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004540 RNA nuclease activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0006401 RNA catabolic process
GO:0016075 rRNA catabolic process
GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing
GO:0071034 CUT catabolic process
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0000177 cytoplasmic exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h25, PDBe:6h25, PDBj:6h25
PDBsum6h25
PubMed30047866
UniProtQ9Y2L1|RRP44_HUMAN Exosome complex exonuclease RRP44 (Gene Name=DIS3)

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