Structure of PDB 6ahd Chain J

Receptor sequence
>6ahdJ (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
LGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVL
GTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKE
DISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKVVVVEGGP
KAQKKFKRLMLHRIKWDEQTSNTKGDDDEKKTNKCVLVWEGTAKDRSFGE
MKFKQCPTENMAREHFKKHGAEHYWDL
3D structure
PDB6ahd Structures of the human pre-catalytic spliceosome and its precursor spliceosome.
ChainJ
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna J K447 R449 R450 R453 Q461 M504 H511 R518 K12 R14 R15 R18 Q26 M69 H76 R83
BS02 rna J P474 K475 N480 R483 R518 K519 N610 T611 P39 K40 N45 R48 R83 K84 N172 T173
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0032991 protein-containing complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:6ahd, PDBe:6ahd, PDBj:6ahd
PDBsum6ahd
PubMed30315277
UniProtO43395|PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Gene Name=PRPF3)

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