Structure of PDB 5whe Chain J

Receptor sequence
>5wheJ (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAVGVGKSALTIQLIQNHFPSYRKQVVIDGETCLLDILDTA
GQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDV
PMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTL
VREIRKH
3D structure
PDB5whe Exceptionally high-affinity Ras binders that remodel its effector domain.
ChainJ
Resolution1.91 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP J V12 G13 G15 K16 S17 A18 F28 N116 K117 D119 L120 S145 A146 V12 G13 G15 K16 S17 A18 F28 N107 K108 D110 L111 S136 A137
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5whe, PDBe:5whe, PDBj:5whe
PDBsum5whe
PubMed29282294
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

[Back to BioLiP]