Structure of PDB 5whb Chain J

Receptor sequence
>5whbJ (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAVGVGKSALTIQLIQNHFDSYRKQVVIDGETCLLDILDTA
GQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDV
PMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTL
VREIRKH
3D structure
PDB5whb Exceptionally high-affinity Ras binders that remodel its effector domain.
ChainJ
Resolution2.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide J E3 K5 Y40 R41 I55 L56 D57 T58 E63 R68 Y71 M72 E3 K5 Y31 R32 I46 L47 D48 T49 E54 R59 Y62 M63
BS02 GDP J V12 G13 G15 K16 S17 A18 F28 N116 K117 D119 L120 S145 A146 V12 G13 G15 K16 S17 A18 F28 N107 K108 D110 L111 S136 A137
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5whb, PDBe:5whb, PDBj:5whb
PDBsum5whb
PubMed29282294
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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