Structure of PDB 5wha Chain J

Receptor sequence
>5whaJ (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]
TEYKLVVVGAVGVGKSALTIQLIQSYRKQVVIDGETCLLDILDTAGQEEY
SAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLV
GNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIR
K
3D structure
PDB5wha Exceptionally high-affinity Ras binders that remodel its effector domain.
ChainJ
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide J K5 Y40 R41 I55 L56 D57 T58 E63 R68 Y71 K4 Y26 R27 I41 L42 D43 T44 E49 R54 Y57
BS02 CA J E63 Y64 E49 Y50
BS03 GDP J V12 G13 G15 K16 S17 A18 N116 K117 D119 S145 A146 K147 V11 G12 G14 K15 S16 A17 N102 K103 D105 S131 A132 K133
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5wha, PDBe:5wha, PDBj:5wha
PDBsum5wha
PubMed29282294
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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