Structure of PDB 5mpa Chain J

Receptor sequence
>5mpaJ (length=386) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
ETHESGIKPYFEQKIQETELKIRSKTENVRRLEAQRNALNDKVRFIKDEL
RLLQEPGSYVGEVIKIVSDKKVLVKVQPEGKYIVDVAKDINVKDLKASQR
VCLRSDSYMLHKVLENKADPLVSLMMVEKVPDSTYDMVGGLTKQIKEIKE
VIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARAVAHHTDCKFIR
VSGAELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSTRVEGSG
GGDSEVQRTMLELLNQLDGFETSKNIKIIMATNRLDILDPALLRPGRIDR
KIEFPPPSVAARAEILRIHSRKMNLTRGINLRKVAEKMNGCSGADVKGVC
TEAGMYALRERRIHVTQEDFELAVGKVMNKNQETAI
3D structure
PDB5mpa Structural insights into the functional cycle of the ATPase module of the 26S proteasome.
ChainJ
Resolution4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ADP J M149 V150 P191 G192 T193 G194 K195 T196 L197 I327 G355 A356 K359 M137 V138 P179 G180 T181 G182 K183 T184 L185 I315 G343 A344 K347
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0036402 proteasome-activating activity
Biological Process
GO:0006289 nucleotide-excision repair
GO:0006338 chromatin remodeling
GO:0010604 positive regulation of macromolecule metabolic process
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0070651 nonfunctional rRNA decay
GO:0070682 proteasome regulatory particle assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0034515 proteasome storage granule

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5mpa, PDBe:5mpa, PDBj:5mpa
PDBsum5mpa
PubMed28115689
UniProtQ01939|PRS8_YEAST 26S proteasome regulatory subunit 8 homolog (Gene Name=RPT6)

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