Structure of PDB 4x2t Chain J

Receptor sequence
>4x2tJ (length=511) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
ASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNN
PGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNS
VAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNL
FRFFLETLFYEYMTDERFKSEYIKHLGVYINNADTYKEEVEKARVYYFGT
YYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAY
LSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGS
MIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRP
GDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAM
LYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKY
ADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGF
GVRLLTEFVLN
3D structure
PDB4x2t X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.
ChainJ
Resolution2.729 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K386 R463
Catalytic site (residue number reindexed from 1) K295 R372
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN J D379 D459 E461 D288 D368 E370
BS02 ZN J K374 D379 D399 E461 K283 D288 D308 E370
BS03 TOD J K374 D379 D459 E461 L487 T488 G489 K283 D288 D368 E370 L396 T397 G398
BS04 CO3 J A460 E461 G462 R463 L487 A369 E370 G371 R372 L396
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4x2t, PDBe:4x2t, PDBj:4x2t
PDBsum4x2t
PubMed25645579
UniProtQ8IL11|AMPL_PLAF7 Leucine aminopeptidase (Gene Name=LAP)

[Back to BioLiP]