Structure of PDB 4qij Chain J

Receptor sequence
>4qijJ (length=301) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
ALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRP
HTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRS
GYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGH
SLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIF
FLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKF
AFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRY
F
3D structure
PDB4qij Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues
ChainJ
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287
Catalytic site (residue number reindexed from 1) G92 R97 Y102 R117 H122 G148 S151 D172 S177 D179 G180 A266 Y274
Enzyme Commision number 4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1HA J F299 K302 F286 K289 MOAD: Kd=2.9uM
BS02 1HA J V57 R58 A60 K95 S103 G104 G105 D106 Q107 Y115 I136 L137 W157 G161 T184 D185 V188 S190 F191 V44 R45 A47 K82 S90 G91 G92 D93 Q94 Y102 I123 L124 W144 G148 T171 D172 V175 S177 F178 MOAD: Kd=2.9uM
Gene Ontology
Molecular Function
GO:0008935 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:4qij, PDBe:4qij, PDBj:4qij
PDBsum4qij
PubMed25372686
UniProtP9WNP5|MENB_MYCTU 1,4-dihydroxy-2-naphthoyl-CoA synthase (Gene Name=menB)

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