Structure of PDB 4qii Chain J

Receptor sequence
>4qiiJ (length=297) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVD
ELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQY
ASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHV
VCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGR
TYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNL
LDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF
3D structure
PDB4qii Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues
ChainJ
Resolution1.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G105 R110 Y115 R130 H135 G161 S164 D185 S190 D192 G193 A279 Y287
Catalytic site (residue number reindexed from 1) G88 R93 Y98 R113 H118 G144 S147 D168 S173 D175 G176 A262 Y270
Enzyme Commision number 4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2NE J Y287 F299 K302 Y270 F282 K285
BS02 2NE J V57 R58 A60 S103 G104 G105 D106 Q107 Y115 W157 A159 G161 T184 D185 V188 S190 V40 R41 A43 S86 G87 G88 D89 Q90 Y98 W140 A142 G144 T167 D168 V171 S173
Gene Ontology
Molecular Function
GO:0008935 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:4qii, PDBe:4qii, PDBj:4qii
PDBsum4qii
PubMed25372686
UniProtP9WNP5|MENB_MYCTU 1,4-dihydroxy-2-naphthoyl-CoA synthase (Gene Name=menB)

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