Structure of PDB 4oo1 Chain J

Receptor sequence
>4oo1J (length=493) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
MVEKPQLKFKSPIDNSESHPFIPLLKEKPNALKPLSESLRLVDDDENNPS
HYPHPYEYEIDHQEYSPEILQIREEIPSKSWDDSVPIWVDTSTELESMLE
DLKNTKEIAVNLEHHDYRSYYGIVCLMQISTRERDYLVDTLKLRENLHIL
NEVFTNPSIVKVFHGAFMDIIWLQRDLGLYVVGLFDTYHASKAIGLPRHS
LAYLLENFANFKTSKKYQLADWRIRPLSKPMTAYARADTHFLLNIYDQLR
NKLIESNKLAGVLYESRNVAKRRFEYSKYRPLTPSSEVYSPIEKESPWKI
LMYQYNIPPEREVLVRELYQWRDLIARRDDESPRFVMPNQLLAALVAYTP
TDVIGVVSLTNGVTEHVRQNAKLLANLIRDALRNIKNTNSETKADGILLE
TISVPQIRDVMERFSVLCNSNISKSRAKPVTNSSILLGKILPREEHDIAY
SKDGLPNKVKTEDIRIRAQNFKSALANLEDIIFEIEKPLVVPV
3D structure
PDB4oo1 Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.
ChainJ
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N238 E240 D296 Y361 D365
Catalytic site (residue number reindexed from 1) N111 E113 D169 Y234 D238
Enzyme Commision number 3.1.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna J N238 E240 H241 F294 M295 D296 Y315 K319 S327 L328 Q345 N111 E113 H114 F167 M168 D169 Y188 K192 S200 L201 Q218
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006139 nucleobase-containing compound metabolic process
GO:0044237 cellular metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4oo1, PDBe:4oo1, PDBj:4oo1
PDBsum4oo1
PubMed25043052
UniProtQ12149|RRP6_YEAST Exosome complex exonuclease RRP6 (Gene Name=RRP6)

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