Structure of PDB 4ec4 Chain J

Receptor sequence
>4ec4J (length=108) Species: 9606 (Homo sapiens) [Search protein sequence]
SDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEG
DKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLT
HSLEECLV
3D structure
PDB4ec4 Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.
ChainJ
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0O6 J N249 K297 G306 L307 T308 D309 E314 Q319 W323 Y324 N4 K52 G61 L62 T63 D64 E69 Q74 W78 Y79 BindingDB: IC50=25.4nM
BS02 ZN J C300 C303 H320 C327 C55 C58 H75 C82
External links
PDB RCSB:4ec4, PDBe:4ec4, PDBj:4ec4
PDBsum4ec4
PubMed23166698
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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