Structure of PDB 3uk6 Chain J

Receptor sequence
>3uk6J (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
TKVPEVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFS
LEMSKTEALTQAFRRSIGVRITVSLHEIDVINSRTFLALFTGEIKSEVRE
QINAKVAEWRIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNR
GITRIRGTSYQSPHGIPIDLLDRLLIVSTTPYSEKDTKQILRIRCEEEDM
SEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKRVYSLFLDESRSTQY
3D structure
PDB3uk6 Large-Scale Conformational Flexibility Determines the Properties of AAA+ TIP49 ATPases.
ChainJ
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP J A24 H25 H27 V47 P79 G80 T81 G82 K83 T84 Y362 I403 A14 H15 H17 V37 P69 G70 T71 G72 K73 T74 Y232 I271
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:3uk6, PDBe:3uk6, PDBj:3uk6
PDBsum3uk6
PubMed22748767
UniProtQ9Y230|RUVB2_HUMAN RuvB-like 2 (Gene Name=RUVBL2)

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