Structure of PDB 3j7r Chain J

Receptor sequence

>3j7rJ (length=170) Species: 9823 (Sus scrofa)

ENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVR
SFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFG
IQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRIS
KEEAMRWFQQKHDGIILPGN

3D structure

• PDB: 3j7r Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
• Chain: J
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	J	K19 C21 N23 C25 S51 A53 R54 F60 H71 N97 N98 S100 D101 T102 G106 G108 Y126 G127 L128 D129 Y131 V133	K11 C13 N15 C17 S43 A45 R46 F52 H63 N89 N90 S92 D93 T94 G98 G100 Y118 G119 L120 D121 Y123 V125
BS02	rna	J	P11 M12 R13 R16 Q46 T47 V49 T73 R75 G138 S140 I141 K144 K145 G152 K154 H155	P3 M4 R5 R8 Q38 T39 V41 T65 R67 G130 S132 I133 K136 K137 G144 K146 H147

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation
• GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
• GO:0034504 protein localization to nucleus
• GO:1901798 positive regulation of signal transduction by p53 class mediator

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:3j7r, PDBe:3j7r, PDBj:3j7r
• PDBsum: 3j7r
• PubMed: 24930395
• UniProt: Q29205|RL11_PIG Large ribosomal subunit protein uL5 (Gene Name=RPL11)