Structure of PDB 8ppl Chain It

Receptor sequence
>8pplIt (length=451) Species: 9606 (Homo sapiens) [Search protein sequence]
QPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAI
SGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPD
EFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG
NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFV
QGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRS
FDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMC
KPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAV
GALPEIFTELEISYFLLRRLLGVRAKVQKLSKNEVLMVNIGSLSTGGRVS
AVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPT
V
3D structure
PDB8ppl Universal features of Nsp1-mediated translational shutdown by coronaviruses.
ChainIt
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008135 translation factor activity, RNA binding
GO:0016787 hydrolase activity
GO:0045296 cadherin binding
GO:1990856 methionyl-initiator methionine tRNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ppl, PDBe:8ppl, PDBj:8ppl
PDBsum8ppl
PubMed37802027
UniProtP41091|IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (Gene Name=EIF2S3)

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