Structure of PDB 7tbm Chain I2

Receptor sequence

>7tbmI2 (length=1542) Species: 9606 (Homo sapiens)

MTDLRKLEALQALHAELVAVRQHRFEGLQVLETLLEEQTDAFKALIAKPA
RDTKDREALGKEPKKLKIGEEEYSLNEDFVNDCLKLADELDLNEKESARI
LIDCDAEGDVETQSRPLWECGVIRFHQERKYLLDCMRLILEIAADEDIDA
GLQESFGVAAEDKIFGIPPPWERQVKKFIPRCMEAMKGVRSMLQCMADKA
NARNMLDNQETLDFSRLSLVEQHECLASILHAAVQRHHATIADFQDFIKI
LRKWDKYDHFLIHLIPVLAAYITEFGSPEGMGDLQQARRLNDFICSWALP
VLGAAVRAWWIAEHNGFYLDDTVQDLRGINLDEEDEQRTKQFLDALKEGA
FDFILSVAADCKAQEWQDPSQLGARQWLQRKIPSLPSEPFPFSHFLQHSL
MVHLEGFVDATISNLPDVLRKLRTEEDEQRQLRPNHEQDMDLERFLIIIS
YAYEGRPDAAMSFWEDPDSNLAGFLQWASRRASTPLVSAFCEMLRCLADN
EECATAAHNFLLDEQSLTWSQIFKELEYFTTKVCSEIEPESALMLECYLR
LIAKLATESEIARKRLIMDEDFNLVDTILKLSVGVIPHRLRACIFYVLKA
LMIRKTHEELDAMWRWVEAWMTNPFPGPQECMEMMFREFGTGFEQSNAFI
QLLTTLLVPPEGLNDSVPFPEWLGSSIRTLGIEPYVDFVFDVFANRTKDI
SDPSQLRILRLSCLDFVMVCLVTFNEDLIVLGHESNISIDDAMAATNLAT
YVRLHPFSRVMEWLFNEKVITSLINTIHQDPISLGSASPDSPLVVSILRA
IQVMIKALELQETYLHLVRPEVLRYQGEAGVRRKPVANAAYSAFEDGILS
HLSLVVDLGKYCNLGHAELTLACLKLLEKISTSSRILSAWSPRNKAIVQL
ERNGEGETISASLSASIMATLDPALAASGENYRVKLAILDFLYACLRATP
DQPTIAHQLLGFHCELSKLGIEPKGPFDMQKSLFHSLLNVLITLTVSEEE
QGMRGYLVTLKYRVLRILQLLWKSPLSASLVMDELRATNFLFHMLLREVQ
IQPQLPWDGQLVTGCEFLLSDASLAYIDYLASRAAIFEYIGKELCSVSQN
RIPSIKRQIFDALNGQIFVPLTIPSIFDFFDFINTDYKWEEIPSPHFTYL
KDLDLGPCIGVHYDIRKAQEILALKRKEYEHSQLATPEFLETVELEEKVL
IEWLTVRNRANLLLTARLNLLQAWANLLLVMIESNDFKSTPKMAFLLQAL
QAILPTLEAFSSLKSDEAFELARVAKVLLWKLEQFTVGNLIGDKLFQLFQ
LCLSAISQCSGTPELRSLYYSICYRYLTAVVDTRSVTNARARTLKAITLY
GDRLLNVICDDAYGSDTTCQTAAMILLNALVHTSRASVDCPIIDALNRLN
FIGVLVDSLKEILNEWASPSQQYTSAKLALLLQLCQTRQGAKYVLQANLF
RALEQSGVFVVALERHYALLVALARVVGAAVTARGAHNIVQGRKFLTQHR
GLVVHVLKKNAILAQQALEERIEELAEAFMLLITATGFLEYE

3D structure

• PDB: 7tbm Architecture of the cytoplasmic face of the nuclear pore.
• Chain: I2
• Resolution: 37.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	I2	K1225 E1228	K1138 E1141
BS02	peptide	I2	Q1063 N1072 T1121 F1125 H1126 V1202	Q980 N989 T1038 F1042 H1043 V1119
BS03	peptide	I2	P438 R442 N492 F496	P416 R420 N470 F474

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Mon Nov 25 19:15:54 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '7tbm', asym_id = 'I2', title = 'Architecture of the cytoplasmic face of the nuclear pore.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='7tbm', asym_id='I2', title='Architecture of the cytoplasmic face of the nuclear pore.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005643', uniprot = '', pdbid = '7tbm', asym_id = 'I2'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005643', uniprot='', pdbid='7tbm', asym_id='I2')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>