Structure of PDB 7ax3 Chain I2

Receptor sequence
>7ax3I2 (length=582) Species: 9606 (Homo sapiens) [Search protein sequence]
IPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPR
GSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVT
GTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDM
LMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLDL
MDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFF
LSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEK
EVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGG
ARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAF
ETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERI
VTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIDPQLERQVETIRNLV
DSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLME
ESAEQAQRRDEMLRMYHALKEALSIIGNINTT
3D structure
PDB7ax3 CryoEM structure of the super-constricted two-start dynamin 1 filament.
ChainI2
Resolution3.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG I2 K44 T65 K35 T56
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008017 microtubule binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007032 endosome organization
GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane
GO:0031623 receptor internalization
GO:0048488 synaptic vesicle endocytosis
GO:0050804 modulation of chemical synaptic transmission
GO:0051260 protein homooligomerization
GO:0051289 protein homotetramerization
GO:0097494 regulation of vesicle size
GO:0099049 clathrin coat assembly involved in endocytosis
GO:0099050 vesicle scission
Cellular Component
GO:0001917 photoreceptor inner segment
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0030117 membrane coat
GO:0030139 endocytic vesicle
GO:0031410 cytoplasmic vesicle
GO:0042583 chromaffin granule
GO:0042995 cell projection
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0098684 photoreceptor ribbon synapse
GO:0098793 presynapse
GO:0098835 presynaptic endocytic zone membrane
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ax3, PDBe:7ax3, PDBj:7ax3
PDBsum7ax3
PubMed34518553
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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