Structure of PDB 8xgc Chain I

Receptor sequence
>8xgcI (length=745) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NAADFSLTVLRARIALLATAIGGPDYTSQIDPPPYKLGDDCLACLKDLKR
WFKLVDDQQKRWDVAMAVAEYRILTDDLLPILIDWENKCSLAAKLAKNNP
DHEEFRNKAYYDKIALNCLQLLVLMTWPLIVTEQSSSNQITLYGELKKHQ
LVYKKTILSMESGKVLRAAIRLALDVIKIDRLSRTPRDNMVLKLVLNFFR
NVIAIEPGEFTINTKKSMPKKGITSIDTLPPNVSMDDISLNTVISSFHKN
KVFGFLLTLTSSLSKEFDQDFINIPLLEIMFYFTKDVNQELLFPRTSAGF
ELSKLLQKEHQMRKNVIKHTSARHSRFGGLLSIQTPDKTRLTVSGSQALV
DEKIALQKLDDSKKWNKRIIKKHQSVAAEGLPNSLLNSQTGKAIFFTESN
GKHFKEFINNFIDSGFNILLHSVTNYFTTEQDRMVTLEQVEYLLFFAWFV
KYQLLRSKIDNSADIKQVSEALKEVTFILVSSLLRSAYDLKNWTVTHAGM
IAFNELLNLVSRTKAAQETDIEFIVSRLFSDERIQLLSNLPKIGSKYSLQ
FMKSCIELTHSVLKVLEQYSDDKTLVIEGKSRRQKKFNISEGDITKLIEE
ENVDRDEALDILTSSLRSIEVNFQKVQANYMTEPVIETYINFLERFRELE
DDSIKKVFSFFHRVFVQAKEQALLFRFDLIILLREMLSPDGLDRMSRSRK
YVSQFSDYFLARLKKRLKKSPAWFVGLLFPPLHNSEVGFYQRYGE
3D structure
PDB8xgc Parental histone transfer caught at the replication fork.
ChainI
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide I K104 K107 R181 L184 K261 F265 T268 S271 N443 S447 K94 K97 R171 L174 K251 F255 T258 S261 N410 S414
BS02 dna I R401 R618 H769 R368 R582 H733
BS03 dna I K226 K230 K400 I403 R619 K621 K216 K220 K367 I370 R583 K585
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000076 DNA replication checkpoint signaling
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0007064 mitotic sister chromatid cohesion
GO:0008156 negative regulation of DNA replication
GO:0031297 replication fork processing
GO:0043111 replication fork arrest
GO:0043570 maintenance of DNA repeat elements
GO:0051321 meiotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031298 replication fork protection complex
GO:0043596 nuclear replication fork

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xgc, PDBe:8xgc, PDBj:8xgc
PDBsum8xgc
PubMed38448592
UniProtP53840|TOF1_YEAST Topoisomerase 1-associated factor 1 (Gene Name=TOF1)

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