Structure of PDB 8x15 Chain I

Receptor sequence
>8x15I (length=792) Species: 9606 (Homo sapiens) [Search protein sequence]
KSHAEIAEQAKHEAEIETRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYL
CEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAK
LRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQT
EKYSDLLSQSLNTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGIL
ADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCP
SFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWR
YLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHF
LEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCN
HPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLE
GRVSRYEADTFLPRHRLSRRVLLEVATAPDPPPRPKPVKMPFYLDSLEEK
RKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPG
PSHPTFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHA
CHPPPWLAPRQAAFQEQLASELWPRARPLHRIVCNMRTQFPDLRLIQYDC
GKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGS
TRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNP
TMDAQAQDRCHDVHIYRLISERTVEENILKKANQKRMLGDMA
3D structure
PDB8x15 Structure of nucleosome-bound SRCAP-C in the apo state
ChainI
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna I K164 R167 E174 Q702 R705 R709 Q710 G711 W712 Q730 R737 K74 R77 E84 Q261 R264 R268 Q269 G270 W271 Q289 R296
BS02 dna I R156 R736 R737 R66 R295 R296
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0004386 helicase activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0000786 nucleosome
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0016604 nuclear body
GO:0032991 protein-containing complex
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8x15, PDBe:8x15, PDBj:8x15
PDBsum8x15
PubMed38331872
UniProtQ6ZRS2|SRCAP_HUMAN Helicase SRCAP (Gene Name=SRCAP)

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