Structure of PDB 8rxb Chain I

Receptor sequence
>8rxbI (length=147) Species: 9606 (Homo sapiens) [Search protein sequence]
KDLPIHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKC
KEVTLHKDGPLGETVLECYNCGCRNVFLLGFIPDSVVVLLCRQPCASQSS
QWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEELWKENPS
3D structure
PDB8rxb UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2.
ChainI
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide I L62 E68 V90 V91 V92 L93 W127 L61 E67 V86 V87 V88 L89 W114
BS02 ZN I C9 C31 H41 C8 C30 H40
BS03 ZN I C69 C72 C95 C99 C68 C71 C91 C95
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rxb, PDBe:8rxb, PDBj:8rxb
PDBsum8rxb
PubMed38709891
UniProtQ92900|RENT1_HUMAN Regulator of nonsense transcripts 1 (Gene Name=UPF1)

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