Structure of PDB 8r4o Chain I

Receptor sequence
>8r4oI (length=317) Species: 9606 (Homo sapiens) [Search protein sequence]
RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF
REVQIMKMLSHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMA
EKEARRKFKQIVTAVYFCHSRNIVHRDLKAENLLLDANLNIKIADFGFSN
LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL
PFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQI
CKHKWMKLGDADPNFDRLIAESQQLKPLNEDVLLAMEDMGLDKEQTLQSL
RSDAYDHYSAIYSLLCD
3D structure
PDB8r4o The structures of salt inducible kinase 3 in complex with pharmacological inhibitors reveal determinants for binding and selectivity.
ChainI
Resolution2.725 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XVI I I72 G75 V80 A93 K95 T142 Y144 A145 G148 N193 L195 A205 D206 I11 G14 V19 A32 K34 T81 Y83 A84 G87 N132 L134 A144 D145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8r4o, PDBe:8r4o, PDBj:8r4o
PDBsum8r4o
PubMed38508313
UniProtQ9Y2K2|SIK3_HUMAN Serine/threonine-protein kinase SIK3 (Gene Name=SIK3)

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