Structure of PDB 8ovw Chain I

Receptor sequence

>8ovwI (length=679) Species: 4932 (Saccharomyces cerevisiae)

SLILDDIILSLTKTTLSLLYEKSKQYGLSSPQLQALVRLLCETSIIDTVT
KVYIVENCFLPDGYLTKELLLEIINHLGTPTVFSRYRIQTPPVLQSALCK
WLVHVNISSSIWLHLWQFSFLQKWITPLVIWQATTPVDVKPWKLSIIKRC
AMHPGYRDAPGSATLILQRFQCLVGASSQITESIITINCNRKTLKSHRNL
KLDAHFLSILKRILSRAHPANFPADTVQNTIDMYLSEIHQLGADSTVSLW
DVTSLEQLAQNWPQLHIPNDVDYMMKPRKVMSRDSLKHLYSSIILIKNSR
DESSSPYEWCIWQLKRCFAHQIETPQEVIPIIISVSSMDNKLSSRIIQTF
CNLKYLKLDELTLKKVCGGILPLWKPELISGTREFFVKFMASIFMWSTRD
GHDNNCTFSETCFYVLQMITNWVLDDKLIALGLTLLHDMQSLLTLDKIFN
NATSNRFSTMAFISSLDILTQLSKQTKSDYAIQYLIVGPDIMNKVFSSDD
PLLLSAACRYLVATKNKLMQYPSTNKFVRMQNQYIMDLTNYLYRNKVLSS
KSLFGVSPDFFKQILENLYIPTADFKNAKFFTITGIPALSYICIIILRRL
ETAENTKIKFTSGIINEETFNNFFRVHHDEIGQHGWIKGVNNIHDLRVKI
LMHLSNTANPYRDIAAFLFTYLKSLSKYS

3D structure

• PDB: 8ovw Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere.
• Chain: I
• Resolution: 3.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	I	C213 N214 R215	C189 N190 R191

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005515 protein binding

Biological Process

• GO:0006270 DNA replication initiation
• GO:0007059 chromosome segregation
• GO:0007094 mitotic spindle assembly checkpoint signaling
• GO:0008608 attachment of spindle microtubules to kinetochore
• GO:0034087 establishment of mitotic sister chromatid cohesion
• GO:0051301 cell division
• GO:0051321 meiotic cell cycle

Cellular Component

• GO:0000775 chromosome, centromeric region
• GO:0000776 kinetochore
• GO:0005634 nucleus
• GO:0005694 chromosome

External links

• PDB: RCSB:8ovw, PDBe:8ovw, PDBj:8ovw
• PDBsum: 8ovw
• PubMed: 37506202
• UniProt: Q12748|CENPI_YEAST Inner kinetochore subunit CTF3 (Gene Name=CTF3)