Structure of PDB 8k2v Chain I

Receptor sequence

>8k2vI (length=541) Species: 9606 (Homo sapiens)

YHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERVEHIKLGGGEKAR
ALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITG
IGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVD
SGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAY
VPAMADENIIVRKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGV
SDHWALDDHHALHLTRKVVRNLNYQKKLDVTIEPSEEPLFPADELYGIVG
ANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFARIFGYPVGIVGN
NGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAKDG
AKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISV
MGGEQAANVLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYS
SARVWDDGIIDPADTRLVLGLSFSAALNAPIEKTDFGIFRM

3D structure

• PDB: 8k2v 3-Methylcrotonyl-CoA Carboxylase in BCCP-CTS-CoA state
• Chain: I
• Resolution: 3.52 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BTI	I	F407 Q477	F385 Q455
BS02	BTI	I	A250 T251	A228 T229
BS03	ACO	I	K141 G142 G174 G175 A176 L178 T217	K119 G120 G152 G153 A154 L156 T195

Gene Ontology

Molecular Function

• GO:0004485 methylcrotonoyl-CoA carboxylase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016874 ligase activity

Biological Process

• GO:0006552 L-leucine catabolic process
• GO:0009083 branched-chain amino acid catabolic process
• GO:0015936 coenzyme A metabolic process

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0005829 cytosol
• GO:1905202 methylcrotonoyl-CoA carboxylase complex

External links

• PDB: RCSB:8k2v, PDBe:8k2v, PDBj:8k2v
• PDBsum: 8k2v
• UniProt: Q9HCC0|MCCB_HUMAN Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (Gene Name=MCCC2)