Structure of PDB 8jxl Chain I

Receptor sequence
>8jxlI (length=532) Species: 9606 (Homo sapiens) [Search protein sequence]
YHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERVEHIKLGGGEKAR
ALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITG
IGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVD
SGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAY
VPAMADENIIVRKQGTIFLAGPPVSAEDLGGADLHCRKSGVSDHWALDDH
HALHLTRKVVRNLNYQKKLDVTIEPSEEPLFPADELYGIVGANLKRSFDV
REVIARIVDGSRFTEFKAFYGDTLVTGFARIFGYPVGIVGNNGVLFSESA
KKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAKDGAKMVAAVAC
AQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISVMGGEQAANV
LATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYSSARVWDDGI
IDPADTRLVLGLSFSAALNAPIEKTDFGIFRM
3D structure
PDB8jxl Human 3-methylcrotonyl-CoA carboxylase in BCCP-BCS state with substrate
ChainI
Resolution2.98 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TW3 I I485 Q489 I454 Q458
BS02 TW3 I R78 K141 G174 A176 Y177 L178 F191 T217 G219 R56 K119 G152 A154 Y155 L156 F169 T195 G197
Gene Ontology
Molecular Function
GO:0004485 methylcrotonoyl-CoA carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006552 L-leucine catabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0015936 coenzyme A metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:1905202 methylcrotonoyl-CoA carboxylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jxl, PDBe:8jxl, PDBj:8jxl
PDBsum8jxl
PubMed
UniProtQ9HCC0|MCCB_HUMAN Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (Gene Name=MCCC2)

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