Structure of PDB 8jaw Chain I

Receptor sequence
>8jawI (length=541) Species: 9606 (Homo sapiens) [Search protein sequence]
YHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERVEHIKLGGGEKAR
ALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITG
IGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVD
SGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAY
VPAMADENIIVRKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGV
SDHWALDDHHALHLTRKVVRNLNYQKKLDVTIEPSEEPLFPADELYGIVG
ANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGFARIFGYPVGIVGN
NGVLFSESAKKGTHFVQLCCQRNIPLLFLQNITGFMVGREYEAEGIAKDG
AKMVAAVACAQVPKITLIIGGSYGAGNYGMCGRAYSPRFLYIWPNARISV
MGGEQAANVLATITKDQRAREGKQFSSADEAALKEPIIKKFEEEGNPYYS
SARVWDDGIIDPADTRLVLGLSFSAALNAPIEKTDFGIFRM
3D structure
PDB8jaw Human MCC in BCCP-CTS state
ChainI
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.4.1.4: methylcrotonoyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BTI I Q477 N480 Q455 N458
BS02 BTI I L246 A249 A250 L224 A227 A228
Gene Ontology
Molecular Function
GO:0004485 methylcrotonoyl-CoA carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006552 L-leucine catabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0015936 coenzyme A metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:1905202 methylcrotonoyl-CoA carboxylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jaw, PDBe:8jaw, PDBj:8jaw
PDBsum8jaw
PubMed
UniProtQ9HCC0|MCCB_HUMAN Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (Gene Name=MCCC2)

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