Structure of PDB 8j03 Chain I

Receptor sequence
>8j03I (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
RNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVASCLVLSVFSTIKEYE
KSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFC
VIDIMVLIASIAVLASALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHS
KELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIG
YGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHF
EKRRNPAAGLIQSAWRFYAGLKVSIRAVCVMRFLVSKRKFKESLRPYDVM
DVIEQYSAGHLDMLSRIKSLQSRVDQIVGR
3D structure
PDB8j03 Ligand activation mechanisms of human KCNQ2 channel.
ChainI
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P0T I L299 S303 L220 S224
BS02 P0T I W236 F240 F305 P308 W157 F161 F226 P229
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005249 voltage-gated potassium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j03, PDBe:8j03, PDBj:8j03
PDBsum8j03
PubMed37857637
UniProtO43526|KCNQ2_HUMAN Potassium voltage-gated channel subfamily KQT member 2 (Gene Name=KCNQ2)

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