Structure of PDB 8g8n Chain I

Receptor sequence

>8g8nI (length=209) Species: 9606 (Homo sapiens)

IVLTQSPDFQSVTPKEKVTITCSANSYMYWYQQKPDQSPKLWVHGTSNLA
SGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCHHWSNTQWTFGGGTKVE
IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPV
TKSFNRGEC

3D structure

• PDB: 8g8n XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer.
• Chain: I
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	I	W91 W96	W86 W91

External links

• PDB: RCSB:8g8n, PDBe:8g8n, PDBj:8g8n
• PDBsum: 8g8n
• PubMed: 38164757