Structure of PDB 8fnp Chain I

Receptor sequence

>8fnpI (length=66) Species: 9606,11698

ELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVP
RRKAKIIRDYGKQMAG

3D structure

• PDB: 8fnp Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants.
• Chain: I
• Resolution: 2.2 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	I	R228 R263	R17 R52

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0008270 zinc ion binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:8fnp, PDBe:8fnp, PDBj:8fnp
• PDBsum: 8fnp
• PubMed: 37478179
• UniProt: P12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol);
  P42166