Structure of PDB 8dej Chain I

Receptor sequence

>8dejI (length=535) Species: 882 (Nitratidesulfovibrio vulgaris str. Hildenborough) [Search protein sequence]

LQALHGYYQRMSADPDAGMPPYGTSMENISFALVLDAKGTLRGIEDLREQ
EGKKLRPRKMLVPIAEKKGNGIKPNFLWENTSYILGVDAKGKQERTDKCH
AAFIAHIKAADQDLAAVLQFLEHGSEEVIGSNIVFRIEGEPGFVHERPAA
RQAWANCLNRREQGLCGQCLITGERQKPIAQLHPSIKGGRDGVRGAQAVA
SIVSFNNTAFESYGKEQSINAPVSQEAAFSYVTALNYLLNPSNRQKVTIA
DATVVFWAERSSPAEDIFAGMFDPPESVRFHVLGLSPNAARLSVRFWEVD
TVGHMLDKVGRHYRELEIIPQFNNEQEFPSLSTLLRQTAVLNKTENISPV
LAGGLFRAMLTGGPYPQSLLPAVLGRIRAEHARPEDKSRYRLEVVTYYRA
ALIKAYLIRNRKLEVPVSLDPARTDRPYLLGRLFAVLEKAQEDAVPGANA
TIKDRYLASASANPGQVFHMLLKNASNHTAKLRKDPERKSAIHYEIMMQE
IIDNISDFPVTMSSDEQGLFMIGYYHQRKALFTKK

3D structure

PDB

8dej Structural snapshots of R-loop formation by a type I-C CRISPR Cascade.

Chain

Resolution

2.86 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	I	S227 Y228	S212 Y213
BS02	dna	I	E53 K55 K56 R58 N72 K92 K94 R205 F287 Q393 F394 N396 R408 Y462 K511 R560 H566 E568 F605 K607 K608	E51 K53 K54 R56 N70 K90 K92 R190 F272 Q321 F322 N324 R336 Y390 K439 R488 H493 E495 F532 K534 K535
BS03	dna	I	K69 N72 Q212 N221 A361 R363 V412 R448 A451 H453 R455 N521	K67 N70 Q197 N206 A289 R291 V340 R376 A379 H381 R383 N449

External links

PDB	RCSB:8dej, PDBe:8dej, PDBj:8dej
PDBsum	8dej
PubMed	36805026
UniProt	Q72WF8

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