Structure of PDB 8d3p Chain I

Receptor sequence
>8d3pI (length=218) Species: 272558 (Halalkalibacterium halodurans C-125) [Search protein sequence]
ASNEEDRYLMLSGLQHFQFCKRQWALIHIEQQWEENVRTIEGQHLHKKAD
QPFMKEKRGSKLTVRAMPIQSKNLQISGICDVVEFVQDSEGIELSGVSGS
YKAFPVEYKRGKPKKGDEDIVQLVAQAMCLEEMLVCRIDKGYLFYNEIKH
RVEVPITDALRDKVVQMAKEMHHYYENRHTPKVKTGPFCNNCSLQSICLP
KLMNKRSVKRYIEGRLSE
3D structure
PDB8d3p PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.
ChainI
Resolution4.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.12.1: 5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna I M11 L12 S13 H17 F20 Q24 I28 W34 R39 T40 G79 I80 E108 K110 R111 K115 P188 M10 L11 S12 H16 F19 Q23 I27 W33 R38 T39 G78 I79 E107 K109 R110 K114 P187
BS02 dna I K206 R207 K205 R206
BS03 SF4 I C21 R23 C190 C193 C199 C20 R22 C189 C192 C198
BS04 MN I D82 E108 D81 E107
Gene Ontology
Molecular Function
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8d3p, PDBe:8d3p, PDBj:8d3p
PDBsum8d3p
PubMed36272411
UniProtA0A4Y7WTW2

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