Structure of PDB 8d3m Chain I

Receptor sequence
>8d3mI (length=218) Species: 272558 (Halalkalibacterium halodurans C-125) [Search protein sequence]
ASNEEDRYLMLSGLQHFQFCKRQWALIHIEQQWEENVRTIEGQHLHKKAD
QPFMKEKRGSKLTVRAMPIQSKNLQISGICDVVEFVQDSEGIELSGVSGS
YKAFPVEYKRGKPKKGDEDIVQLVAQAMCLEEMLVCRIDKGYLFYNEIKH
RVEVPITDALRDKVVQMAKEMHHYYENRHTPKVKTGPFCNNCSLQSICLP
KLMNKRSVKRYIEGRLSE
3D structure
PDB8d3m PAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.
ChainI
Resolution3.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.12.1: 5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna I M11 S13 Q16 H17 F20 Q24 W34 R39 T40 G43 H47 G79 I80 K110 R111 N192 S194 M10 S12 Q15 H16 F19 Q23 W33 R38 T39 G42 H46 G78 I79 K109 R110 N191 S193
BS02 MN I D82 E108 Y109 D81 E107 Y108
BS03 SF4 I C21 R23 Q24 F189 C190 C193 C199 P201 C20 R22 Q23 F188 C189 C192 C198 P200
Gene Ontology
Molecular Function
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8d3m, PDBe:8d3m, PDBj:8d3m
PDBsum8d3m
PubMed36272411
UniProtA0A4Y7WTW2

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