Structure of PDB 8d3c Chain I

Receptor sequence
>8d3cI (length=1305) Species: 9606 (Homo sapiens) [Search protein sequence]
STARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGK
RVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLS
GEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTL
TSDPYDFANSWALSSGEQWCERASPPSSSCGLWEQCQLLKSTSVFARCHP
LVDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHS
ACSPVCPAGMEYRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDE
GLCVESTECPCVHSGKRYPPGTSLSRDCNTCICRNSQWICSNEECPGECL
VTGQSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIETVQCADDRDAV
CTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDLRIQHTVTAS
VRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPS
GLAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTS
PTFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVR
VAWREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFC
PPGLYMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCT
MSGCAKTCQNYDLECMSMLCPPGMVRHENRCVALERCPCFHQGKEYAPGE
TVKIGCNTCVCRDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQ
YVLVQDYCGSNPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGE
VNVKRPMKDETHFEVVESGRYIILLLGKALSVVWDRHLSISVVLKQTYQE
KVCGLCGNFDGIQNNDLTSSNLQVEEDPVDFGNSWKVSSQCADTRKVPLD
SSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPEPYLDVCIYDTCS
CESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERNLRENGY
ECEWRYNSCAPACQVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTC
VDPEDCPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRI
SQKWVRVAVVEYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSE
VLKYTLFQIFSKIDRPEASRIALLLMASQEPQRMSRNFVRYVQGLKKKKV
IVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRDEIVSYLCD
LAPEA
3D structure
PDB8d3c Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange.
ChainI
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA I D879 N998 D1000 I1002 N1005 D1006 D789 N908 D910 I912 N915 D916
BS02 CA I D400 N526 N528 N530 D533 D534 D361 N487 N489 N491 D494 D495
BS03 CA I D47 N164 N166 F168 A169 D171 D172 D17 N134 N136 F138 A139 D141 D142
External links
PDB RCSB:8d3c, PDBe:8d3c, PDBj:8d3c
PDBsum8d3c
PubMed35776905
UniProtP04275|VWF_HUMAN von Willebrand factor (Gene Name=VWF)

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