Structure of PDB 8br4 Chain I

Receptor sequence
>8br4I (length=339) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MTVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNSTLAHLL
KFDSILGRLPCDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVV
VESTGLFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQ
NIISNASCTTNCLAPLAKVLDDEFGIVKGLMTTIHAYTQDQNLQDGPHKD
LRRARAAALNIVPTSTGAAKAIGLVMPQLKGKLDGYALRVPIPTGSVTDL
TVDLSTRASVDEINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIF
DSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTLVGKSL
3D structure
PDB8br4 Structure of GAPDH from Mycobacterium tuberculosis
ChainI
Resolution3.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD I G9 G11 R12 I13 D39 T104 G105 S127 A128 C158 N320 G9 G11 R12 I13 D39 T104 G105 S127 A128 C158 N320
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8br4, PDBe:8br4, PDBj:8br4
PDBsum8br4
PubMed
UniProtP9WN83|G3P_MYCTU Glyceraldehyde-3-phosphate dehydrogenase (Gene Name=gap)

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