Structure of PDB 7xhn Chain I

Receptor sequence
>7xhnI (length=517) Species: 9606 (Homo sapiens) [Search protein sequence]
EEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDI
LLNIALSGKFGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTK
VLFYRWLVAMFDFIDRKEQINLLYGFFFASLQDDALCPYVCHLLYLLTKK
ENVKPFRVRKLLDLQAKMGMQPHLQALLSLYKFFAPALISVIYFKNSENL
WKTALLAVKQRNRGPSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEE
CIWYKVNNYEHGKEFTNFLDTIIRAECFLQEGFYSCEAFLYKSLPLWDGL
CCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQLFFTSTIYFKCSVLQSLKE
LLQNWLLWLSMDIHMKLGGSMNSVSKLIHYVGWLSTTAMRLESNNTFLLH
FILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHR
YRKNLTAAKKNENFSSKTYQEFNHYLTSMVGCLHPSFLSYAVSFKWSWYL
DYLFSQGLQGLKLFIRS
3D structure
PDB7xhn Structural insights into human CCAN complex assembled onto DNA.
ChainI
Resolution3.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide I S453 Y488 C491 S492 Q495 F560 S304 Y339 C342 S343 Q346 F401
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0007059 chromosome segregation
GO:0007548 sex differentiation
GO:0034080 CENP-A containing chromatin assembly
GO:0034508 centromere complex assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000939 inner kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0016604 nuclear body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xhn, PDBe:7xhn, PDBj:7xhn
PDBsum7xhn
PubMed36085283
UniProtQ92674|CENPI_HUMAN Centromere protein I (Gene Name=CENPI)

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