Structure of PDB 7wl0 Chain I

Receptor sequence
>7wl0I (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
QLQKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHTV
DRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQ
KLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDS
ALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIK
ERRAVIILRKTRLDAPRL
3D structure
PDB7wl0 Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes.
ChainI
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna I P128 L129 R130 Y139 Y141 G142 I201 V202 S203 H204 V205 D206 P207 F234 I237 T265 P54 L55 R56 Y65 Y67 G68 I127 V128 S129 H130 V131 D132 P133 F160 I163 T191
BS02 MN I H204 D206 H266 H130 D132 H192
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7wl0, PDBe:7wl0, PDBj:7wl0
PDBsum7wl0
PubMed35333330
UniProtQ6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)

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