Structure of PDB 7wf4 Chain I

Receptor sequence
>7wf4I (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
RQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINL
FDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSR
KHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAM
YWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELF
HKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGR
RQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMEN
IGAIQVLPKLSSSIIHEIDSILGNKPYS
3D structure
PDB7wf4 Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.
ChainI
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP I G55 R189 W243 S244 P245 L246 S252 K254 R264 G323 Q329 G22 R156 W210 S211 P212 L213 S219 K221 R231 G290 Q296
Gene Ontology
Molecular Function
GO:0005249 voltage-gated potassium channel activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wf4, PDBe:7wf4, PDBj:7wf4
PDBsum7wf4
PubMed35091471
UniProtQ13303|KCAB2_HUMAN Voltage-gated potassium channel subunit beta-2 (Gene Name=KCNAB2)

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