Structure of PDB 7vtq Chain I

Receptor sequence
>7vtqI (length=789) Species: 10090 (Mus musculus) [Search protein sequence]
DYCKMYRRHVRSRFYSISVDLNSRYTQLQLVKESLKLELLFEPEDGHSEP
VHTVVFQGAAGIGKTILARKIMLDWALGKLFKDKFDYLFFIHCREVSLRT
PRSLADLIVSCWPDPNPPVCKILRKPSRILFLMDGFDELQGAFDEHIGEV
CTDWQKAVRGDILLSSLIRKKLLPKASLLITTRPVALEKLQHLLDHPRHV
EILGFSEAKRKEYFFKYFSNELQAREAFRLIQENEVLFTMCFIPLVCWIV
CTGLKQQMETGKSLAQTSKTTTAVYVFFLSSLLFSDYLQGLCSLAADGIW
NQKILFEECDLRKHGLQKTDVSAFLRMNRFYSFSHMTFQEFFAAMYYLLN
RDVKVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQVR
LELLKWIEVKAKAKKLQWQPSQLELFYCLYEMQEEDFVQSAMDHFPKIEI
NLSTRMDHVVSSFCIKNCHRVKTLSLGFFHTSSFCRGLFSSLSTNRSLTE
LDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLSHQCCFDISSVLS
SSQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLQKLWLVSCCLTSACCQ
DLALVLSSNHSLTRLYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSG
LTSICCSALTSVLKTNQNFTHLYLRSNALGDTGLRLLCEGLLHPDCKLQM
LELDNCSLTSHSCWNLSTILTHNHSLRKLNLGNNDLGDLCVVTLCEVLKQ
QGCLLQSLQLGEMYLNRETKRALEALQEEKPELTIVFEI
3D structure
PDB7vtq Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
ChainI
Resolution3.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP I Y164 T165 G225 G227 K228 T229 I230 Y377 P408 W412 H518 Y25 T26 G61 G63 K64 T65 I66 Y213 P244 W248 H335
BS02 7YN I A223 A224 R347 I407 F573 R576 E627 Y630 A59 A60 R183 I243 F370 R373 E424 Y427
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0035591 signaling adaptor activity
GO:0043531 ADP binding
GO:0043565 sequence-specific DNA binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0140297 DNA-binding transcription factor binding
GO:0140299 molecular sensor activity
GO:1901981 phosphatidylinositol phosphate binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002526 acute inflammatory response
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0002830 positive regulation of type 2 immune response
GO:0006954 inflammatory response
GO:0007231 osmosensory signaling pathway
GO:0009595 detection of biotic stimulus
GO:0014070 response to organic cyclic compound
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0044546 NLRP3 inflammasome complex assembly
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051260 protein homooligomerization
GO:0051607 defense response to virus
GO:0070269 pyroptotic inflammatory response
GO:0071222 cellular response to lipopolysaccharide
GO:0071224 cellular response to peptidoglycan
GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction
GO:2000321 positive regulation of T-helper 17 cell differentiation
GO:2000553 positive regulation of T-helper 2 cell cytokine production
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0031021 interphase microtubule organizing center
GO:0061702 canonical inflammasome complex
GO:0072559 NLRP3 inflammasome complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7vtq, PDBe:7vtq, PDBj:7vtq
PDBsum7vtq
PubMed35254907
UniProtQ8R4B8|NLRP3_MOUSE NACHT, LRR and PYD domains-containing protein 3 (Gene Name=Nlrp3)

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