Structure of PDB 7rh5 Chain I

Receptor sequence

>7rh5I (length=223) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]

QSALLRTGKQLFETSCVSCHGANLQGVPDRGPSLIGTGEAAVYFQVSTGR
MPAMRGEAQAPSKPPHFDESQIDALGAYVQANGGGPTVPRDDHGAVAQES
LIGGDVARGGDLFRLNCASCHNFTGKGGALSSGKYAPDLGDANPAQIYTA
MLTGPQNMPKFSDRQLTPDEKRDIVAYVRESAETPSYGGYGLGGFGPAPE
GMAMWIIGMVAAIGVAMWIGSRA

3D structure

PDB

7rh5 Structure of mycobacterial CIII 2 CIV 2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203).

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

7.1.1.8: quinol--cytochrome-c reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MQ9	I	P270 M273	P199 M202
BS02	HEC	I	S86 C87 C90 H91 P103 L105 T108 A112 V113 M122 A124 Q227	S15 C16 C19 H20 P32 L34 T37 A41 V42 M51 A53 Q156
BS03	HEC	I	R121 N187 C188 C191 H192 P208 L210 I218 M222 P226 Q227 M229 P230 F232	R50 N116 C117 C120 H121 P137 L139 I147 M151 P155 Q156 M158 P159 F161
BS04	MQ9	I	M273 W276	M202 W205
BS05	9YF	I	K197 D209 G211 A253 Y261 M273 I278	K126 D138 G140 A182 Y190 M202 I207

Gene Ontology

	Molecular Function
GO:0009055	electron transfer activity
GO:0020037	heme binding

View graph for
Molecular Function

External links

PDB	RCSB:7rh5, PDBe:7rh5, PDBj:7rh5
PDBsum	7rh5
PubMed	34590581
UniProt	I7FPH1

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