Structure of PDB 7qo5 Chain I

Receptor sequence
>7qo5I (length=384) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
RCKLKLLRMERIKDHLLLEEEFVSNSEILKPFEKKQEEEKKQLEEIRGNP
LSIGTLEEIIDDDHAIVTSPTMPDYYVSILSFVDKELLEPGCSVLLHHKT
MSIVGVLQDDADPMVSVMKMDKSPTESYSDIGGLESQIQEIKESVELPLT
HPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELI
QKYLGDGPRLCRQIFKVAGENAPSIVFIDEIDAIGTKRYDSNSGGEREIQ
RTMLELLNQLDGFDDRGDVKVIMATNKIETLDPALIRPGRIDRKILFENP
DLSTKKKILGIHTSKMNLSEDVNLETLVTTKDDLSGADIQAMCTEAGLLA
LRERRMQVTAEDFKQAKERVMKNKVEENLEGLYL
3D structure
PDB7qo5 Allosteric control of Ubp6 and the proteasome via a bidirectional switch.
ChainI
Resolution6.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP I D314 R340 D261 R287
BS02 ATP I I184 G226 T227 G228 K229 T230 L231 I361 A390 Q393 I131 G173 T174 G175 K176 T177 L178 I308 A337 Q340
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010604 positive regulation of macromolecule metabolic process
GO:0031503 protein-containing complex localization
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043171 peptide catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0070651 nonfunctional rRNA decay
GO:0070682 proteasome regulatory particle assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008540 proteasome regulatory particle, base subcomplex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7qo5, PDBe:7qo5, PDBj:7qo5
PDBsum7qo5
PubMed35149681
UniProtP40327|PRS4_YEAST 26S proteasome regulatory subunit 4 homolog (Gene Name=RPT2)

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