Structure of PDB 7mip Chain I

Receptor sequence
>7mipI (length=540) Species: 10090 (Mus musculus) [Search protein sequence]
MKYILVTGGVISGIGKGVIASSVGTILKSCGLHVTSIKIDPYINIDAGTF
SPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINK
ERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGT
VGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNS
VRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSI
YRVPLLLEEQGVVDYFLRRLDLPLMKWKEMADRYDRLLETCSIALVGKYT
KFSDSYASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEEPVRYHEAW
QKLCSAHGVLVPGGFGVRGTEGKIQAIAWARKQKKPFLGVCLGMQLAVVE
FSRNVLGWQDANSTEFDPKTSHPVVIDMPTMRLGKRRTLFQTKNSVMRKL
YGDTDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEGERMEIVELEDH
PFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLPHYLQK
3D structure
PDB7mip Structural basis for isoform-specific inhibition of human CTPS1.
ChainI
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003883 CTP synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
GO:0042802 identical protein binding
Biological Process
GO:0002376 immune system process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0044210 'de novo' CTP biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0097268 cytoophidium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mip, PDBe:7mip, PDBj:7mip
PDBsum7mip
PubMed34583994
UniProtP70698|PYRG1_MOUSE CTP synthase 1 (Gene Name=Ctps1)

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