Structure of PDB 7dy2 Chain I

Receptor sequence

>7dy2I (length=467) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence]

IAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNGIIEF
DEPGVFVTFEETPQDIIKNARSFGWDLAKLVDEGKLFILDASPDPEGQFD
LSALIERINYAIQKYRARRVSIDSVTSVASSVVRRELFRLVARLKQIGAT
TVMTTERIEEYGPIARYGVEEFVSDNVVILRNVLEGERRRRTLEILKLRG
TSHMKGEYPFTITDHGINIFPLGTQRSSNVRVSSGVVRLDEMCGGGFFKD
SIILATGATGTGKTLLVSRFVENACANKERAILFAYEESRAQLLRNAYSW
GMDFEEMERQNLLKIVCAYPESAGLEDHLQIIKSEINDFKPARIAIDSLS
ALARGVSNNAFRQFVIGVTGYAKQEEITGLFTNTSDQFMGAHSITDSHIS
TITDTIILLQYVEIRGEMSRAINVFKMRGSWHDKAIREFMISDKGPDIKD
SFRNFERIISGSPTRIT

3D structure

PDB

7dy2 Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria.

Chain

Resolution

3.04 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	I	K224 L225 G227 T228 S229 H230	K197 L198 G200 T201 S202 H203
BS02	ATP	I	K457 M458 R459 S461	K426 M427 R428 S430
BS03	ADP	I	G49 G51 K52 T53 L54 S89 F90 I239 T240	G32 G34 K35 T36 L37 S72 F73 I212 T213
BS04	ADP	I	G291 T292 G293 K294 T295 W331 R451 I472 S473	G260 T261 G262 K263 T264 W300 R420 I441 S442

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0044024	histone H2AS1 kinase activity
GO:0046872	metal ion binding
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007623	circadian rhythm
GO:0009649	entrainment of circadian clock
GO:0016310	phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0042754	negative regulation of circadian rhythm
GO:0048511	rhythmic process
GO:0070297	regulation of phosphorelay signal transduction system

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7dy2, PDBe:7dy2, PDBj:7dy2
PDBsum	7dy2
PubMed	35427168
UniProt	Q79PF4\|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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