Structure of PDB 7crr Chain I

Receptor sequence
>7crrI (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
NSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECL
NRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSI
KKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPK
GNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDC
LGNGRTECHCGADNCSGFLGVR
3D structure
PDB7crr Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
ChainI
Resolution3.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.370: [histone H3]-lysine(4) N-dimethyltransferase.
2.1.1.371: [histone H3]-lysine(27) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM I R1155 G1156 F1199 N1223 Y1261 L1284 R90 G91 F134 N158 Y196 L219
BS02 ZN I C1226 C1280 C161 C215
BS03 ZN I C1098 C1100 C1108 C1114 C33 C35 C43 C49
BS04 ZN I C1108 C1123 C1134 C43 C58 C69
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:7crr, PDBe:7crr, PDBj:7crr
PDBsum7crr
PubMed33361816
UniProtQ9BZ95|NSD3_HUMAN Histone-lysine N-methyltransferase NSD3 (Gene Name=NSD3)

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