Structure of PDB 6ztr Chain I

Receptor sequence
>6ztrI (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
WVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVF
AVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQ
NDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIH
SQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGS
TTTAVAVVEILDAN
3D structure
PDB6ztr PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies.
ChainI
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA I N209 H211 D241 D243 N250 D302 N101 H103 D133 D135 N142 D194
BS02 CA I E118 E176 D207 Q208 D210 D243 E10 E68 D99 Q100 D102 D135
BS03 CA I E118 D174 E176 D210 E10 D66 E68 D102
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ztr, PDBe:6ztr, PDBj:6ztr
PDBsum6ztr
PubMed33879555
UniProtP22223|CADH3_HUMAN Cadherin-3 (Gene Name=CDH3)

[Back to BioLiP]